Product SpecificationHost | Rabbit | Antigen | PGC1α | Synonyms | Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; PPARGC1A; LEM6; PGC1; PGC1A; PPARGC1 | Immunogen | Synthetic Peptide | Location | Cytoplasm, Nucleus | Accession | Q9UBK2 | Clone Number | S-1199-234 | Antibody Type | Recombinant mAb | Isotype | IgG | Application | WB | Reactivity | Ms, Rt | Positive Sample | mouse kidney, mouse heart, rat kidney, rat heart | Predicted Reactivity | Pg, Bv | Purification | Protein A | Concentration | 0.25 mg/ml | Conjugation | Unconjugated | Physical Appearance | Liquid | Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 | Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilutionapplication | dilution | species | WB | 1:5000 | Ms, Rt |
BackgroundPGC1α (Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha) is a transcriptional coactivator that plays a pivotal role in regulating energy metabolism and is implicated in various biological processes. PGC1α acts as a coactivator for several nuclear receptors and transcription factors, enhancing their transcriptional activity. It is involved in the regulation of genes that are crucial for adaptive thermogenesis and energy metabolism. PGC1α coordinates the expression of multiple genes involved in glucose and fatty acid metabolism, playing a significant role in metabolic reprogramming in response to dietary changes. It is also involved in the regulation of circadian rhythms and energy metabolism by activating RORA and RORC, which in turn control the oscillatory expression of clock genes such as ARNTL/BMAL1 and NR1D1. PGC1α has been considered a potential therapeutic target for treating type 2 diabetes, obesity, cardiomyopathy, and other metabolic disorders. PGC1α can suppress cholesterol synthesis and reduce serum cholesterol levels. It upregulates the expression of genes like Insig-1 and Insig-2, which inhibit cholesterol synthesis in cells like HepG2. It also promotes the transformation of cholesterol into bile acids, thereby affecting cholesterol metabolism and serum cholesterol levels. Moreover, PGC1α is a key regulator of mitochondrial biogenesis and function, which is crucial for energy production and cellular metabolism. It is involved in the adaptive response to changes in energy demand and nutrient availability. bio-equip.cn
AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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