PSD-95 (Postsynaptic Density Protein-95) is a protein highly enriched in the postsynaptic density of excitatory synapses in the central nervous system. It is a major synaptic scaffolding protein that contains three PDZ domains, one SH3 domain, and a GUK domain. These domains enable PSD-95 to interact with a variety of proteins, including NMDA and AMPA receptors, thereby playing a crucial role in synaptic plasticity and signal transduction. PSD-95 is involved in regulating the maturation and function of synapses, influencing long-term potentiation (LTP) and long-term depression (LTD). It modulates the stability and function of receptors and ion channels at the postsynaptic membrane through interactions with them. Abnormalities in PSD-95 function are associated with various neuropsychiatric disorders, including autism, schizophrenia, and intellectual disability. Mutations in the gene encoding PSD-95 in these disorders may lead to synaptic dysfunction.