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Home >Products> Reagents >Antibody> Syntenin Recombinant Rabbit mAb (S-1692-5)
Syntenin Recombinant Rabbit mAb (S-1692-5)
Syntenin Recombinant Rabbit mAb (S-1692-5)
Origin of place Singapore
Model S0B1108-25μl
Supplier ANT BIO PTE.LTD.
Price 100
Hits 3
Updated 8/27/2025
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Product Specification


HostRabbit
AntigenSyntenin
SynonymsMelanoma differentiation-associated protein 9 (MDA-9); Pro-TGF-alpha cytoplasmic domain-interacting protein 18 (TACIP18); Scaffold protein Pbp1; Syndecan-binding protein 1; SDCBP; MDA9; SYCL
ImmunogenSynthetic Peptide
LocationCell membrane, Cytoplasm, Nucleus
AccessionO00560
Clone NumberS-1692-5
Antibody TypeRecombinant mAb
IsotypeIgG
ApplicationWB, IHC-P, ICC, IP
ReactivityHu
Positive SampleHeLa, A549, HepG2
PurificationProtein A
Concentration0.5 mg/ml
ConjugationUnconjugated
Physical AppearanceLiquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


applicationdilutionspecies
WB1:1000Hu
IP1:50Hu
IHC-P1:250Hu
ICC1:500Hu

Background

Syntenin is a multifunctional intracellular adaptor protein that plays a crucial role in various signaling pathways and cellular functions. It is composed of two adjacent tandem PDZ (PSD-95/Discs large/Zonula occludens-1) domains, which recognize multiple peptide motifs with low to moderate affinity. Syntenin interacts with a plethora of proteins, regulating the architecture of the cell membrane. Increases in Syntenin levels can induce the metastasis of tumor cells, neurite protrusion in neuronal cells, and exosome biogenesis in various cell types. It is also involved in the subcellular trafficking of binding partners during endocytic and exocytic events. Additionally, syntenin interacts with the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2), which influences its localization and function at the plasma membrane. Furthermore, syntenin is involved in the regulation of exosome biogenesis, which is a key process in intercellular communication, including neuron-neuron, neuron-glia, and glia-glia crosstalk, as well as in tumor metastasis, cell proliferation, and angiogenesis. Syntenin interacts with proteins involved in exosome biogenesis, indicating its role in intracellular membrane rearrangement and cargo loading into exosomes.

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