Product SpecificationHost | Rabbit | Antigen | Angiopoietin-like 4/ANGPTL4 | Synonyms | Hepatic fibrinogen/angiopoietin-related protein (HFARP); ARP4; PGAR | Immunogen | Synthetic Peptide | Location | Secreted, Extracellular matrix | Accession | Q9BY76 | Clone Number | S-1605-42 | Antibody Type | Recombinant mAb | Isotype | IgG | Application | WB, IHC-P, ICC | Reactivity | Hu, Ms, Rt | Positive Sample | HEK-293, HepG2, A549, THP-1, 3T3-L1 | Predicted Reactivity | Bv, Pg | Purification | Protein A | Concentration | 2 mg/ml | Conjugation | Unconjugated | Physical Appearance | Liquid | Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 | Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilutionapplication | dilution | species | WB | 1:1000 | Hu, Ms | IHC-P | 1:100 | Hu, Ms, Rt | ICC | 1:500 | Hu |
BackgroundAngiopoietin-like 4 (ANGPTL4) is a multifaceted protein that belongs to the angiopoietin-like protein family. One of the primary functions of ANGPTL4 is to govern fatty acid delivery to cells by inhibiting lipoprotein lipase (LPL) activity. Overexpression of ANGPTL4 in mice leads to hypertriglyceridemia, while deficiency reduces circulating lipids and lowers the risk of coronary artery disease in humans. ANGPTL4 is highly expressed in adipose tissues and liver, where it primarily regulates lipid metabolism. In addition to its metabolic roles, ANGPTL4 is also expressed in vascular endothelium and has been reported to regulate endothelial cell functions such as vascular inflammation, nitric oxide production, angiogenesis, and vascular permeability. ANGPTL4 has been identified as a central player in energy homeostasis, at least in part, through its inhibitory interaction with LPL. The fibrinogen-like domain of ANGPTL4 interacts and activates specific integrins, which facilitate wound healing, modulate vascular permeability, and regulate reactive oxygen species (ROS) levels to promote tumorigenesis. bio-equip.cn
AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
|