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Caspase-9 Recombinant Rabbit mAb (S-1541-20)
Caspase-9 Recombinant Rabbit mAb (S-1541-20)
Origin of place Singapore
Model S0B1116-25μl
Supplier ANT BIO PTE.LTD.
Price 100
Hits 3
Updated 8/27/2025
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Product Specification


HostRabbit
AntigenCaspase-9
SynonymsCASP-9; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3 (APAF-3); ICE-like apoptotic protease 6 (ICE-LAP6)
ImmunogenSynthetic Peptide
LocationCytoplasm
AccessionP55211
Clone NumberS-1541-20
Antibody TypeRecombinant mAb
IsotypeIgG
ApplicationWB
ReactivityHu, Ms, Rt
Positive SampleTHP-1, HepG2, C2C12, NIH/3T3, mouse brain, mouse heart, mouse spleen, rat brain, rat heart, rat spleen
PurificationProtein A
Concentration0.5 mg/ml
ConjugationUnconjugated
Physical AppearanceLiquid
Storage BufferPBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


applicationdilutionspecies
WB1:1000Hu, Ms, Rt

Background

Caspase-9 is a cysteine-aspartic protease that plays a critical role as an initiator of the intrinsic apoptosis pathway, also known as the mitochondrial pathway. Caspase-9 is activated in response to various apoptotic stimuli, such as DNA damage, growth factor deprivation, and oxidative stress. It is a key initiator caspase that, once activated, can activate downstream effector caspases like Caspase-3, -6, and -7, leading to the execution of apoptosis. Recent research has revealed that Caspase-9 has functions beyond apoptosis, including the regulation of cellular differentiation/maturation, innate immunity, mitochondrial homeostasis, and autophagy. It has been shown that Caspase-9 can drive neurovascular injury through nonapoptotic endothelial cell dysfunction. Caspase-9 has also been implicated in the regulation of autophagy through its non-apoptotic functions. It maintains mitochondrial homeostasis, which is crucial for the maturation of autophagosomes. Genetic variations in the CASP9 gene have been linked to various diseases, including cancers, neurological disorders, autoimmune pathologies, and lumbar disc disease. Alterations in Caspase-9 expression, activity, or function may be associated with acute and chronic neurodegeneration, retinal neuropathy, and other conditions.

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