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GSK3β Recombinant Rabbit mAb (S-1209-170)
GSK3β Recombinant Rabbit mAb (S-1209-170)
Origin of place Singapore
Model S0B1114-25μl
Supplier ANT BIO PTE.LTD.
Price 100
Hits 3
Updated 8/27/2025
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Product Specification


HostRabbit
AntigenGSK3β
SynonymsGlycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B
ImmunogenSynthetic Peptide
LocationCytoplasm, Nucleus, Cell membrane
AccessionP49841
Clone NumberS-1209-170
Antibody TypeRecombinant mAb
IsotypeIgG
ApplicationWB, IHC-P, ICC, IP
ReactivityHu, Ms, Rt
Positive SampleHeLa, A431, MCF7, NIH/3T3, PC-12
Predicted ReactivityS. citellus
PurificationProtein A
Concentration0.5 mg/ml
ConjugationUnconjugated
Physical AppearanceLiquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


applicationdilutionspecies
WB1:1000Hu, Ms, Rt
IP1:50Hu
IHC-P1:500Hu, Ms, Rt
ICC1:500Hu, Ms

Background

GSK-3β (Glycogen Synthase Kinase 3 beta) is a multifunctional serine/threonine protein kinase that is highly conserved across eukaryotes. GSK-3β is expressed in all cell types and is particularly abundant in the brain. It regulates cell proliferation, survival, gene expression, cellular architecture, and neural development and plasticity. Dysregulation of GSK-3β is implicated in numerous disorders, including cancers, diabetes, and neurodegenerative diseases. In Alzheimer’s disease, GSK-3β contributes to the pathological phosphorylation of tau protein. GSK-3β plays a significant role in neuronal apoptosis, and its inhibition reduces the expression of alpha-Synuclein (α-Synuclein), making it a potential therapeutic target for neurodegenerative disorders like Parkinson's disease (PD).

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