Product SpecificationHost | Rabbit | Antigen | GSK3β | Synonyms | Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B | Immunogen | Synthetic Peptide | Location | Cytoplasm, Nucleus, Cell membrane | Accession | P49841 | Clone Number | S-1209-170 | Antibody Type | Recombinant mAb | Isotype | IgG | Application | WB, IHC-P, ICC, IP | Reactivity | Hu, Ms, Rt | Positive Sample | HeLa, A431, MCF7, NIH/3T3, PC-12 | Predicted Reactivity | S. citellus | Purification | Protein A | Concentration | 0.5 mg/ml | Conjugation | Unconjugated | Physical Appearance | Liquid | Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 | Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilutionapplication | dilution | species | WB | 1:1000 | Hu, Ms, Rt | IP | 1:50 | Hu | IHC-P | 1:500 | Hu, Ms, Rt | ICC | 1:500 | Hu, Ms |
BackgroundGSK-3β (Glycogen Synthase Kinase 3 beta) is a multifunctional serine/threonine protein kinase that is highly conserved across eukaryotes. GSK-3β is expressed in all cell types and is particularly abundant in the brain. It regulates cell proliferation, survival, gene expression, cellular architecture, and neural development and plasticity. Dysregulation of GSK-3β is implicated in numerous disorders, including cancers, diabetes, and neurodegenerative diseases. In Alzheimer’s disease, GSK-3β contributes to the pathological phosphorylation of tau protein. GSK-3β plays a significant role in neuronal apoptosis, and its inhibition reduces the expression of alpha-Synuclein (α-Synuclein), making it a potential therapeutic target for neurodegenerative disorders like Parkinson's disease (PD). bio-equip.cn
AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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