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APC Mouse Anti-Human CD1a Antibody (S-R527)
APC Mouse Anti-Human CD1a Antibody (S-R527)
Origin of place Singapore
Model S0B1675-20T
Supplier ANT BIO PTE.LTD.
Price 145
Hits 3
Updated 8/27/2025
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Product Specification


HostMouse
AntigenCD1a
SynonymsT-cell surface glycoprotein CD1a; T-cell surface antigen T6/Leu-6 (hTa1 thymocyte antigen)
LocationCell membrane
AccessionP06126
Clone NumberS-R527
Antibody TypeMouse mAb
IsotypeIgG1,k
ApplicationFCM
ReactivityHu
Positive SampleMOLT-4
Predicted ReactivityOr
PurificationProtein G
Concentration0.05mg/ml
ConjugationAPC
Physical AppearanceLiquid
Storage BufferPBS, 1% BSA, 0.3% Proclin 300
Stability & Storage12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


applicationdilutionspecies
FCM5 μl per million cells in 100μl volumeHu

Background

CD1a is a cell surface glycoprotein that is part of the CD1 family of antigen-presenting molecules. It is primarily expressed on Langerhans cells, a type of dendritic cell found in the epidermis of the skin, as well as on certain T-cell leukemias and thymocytes. CD1a is involved in the presentation of lipid antigens to T-cells, particularly to a subset of T-cells known as invariant natural killer T (iNKT) cells. CD1a plays a crucial role in immune responses, particularly in the initiation and amplification of local and systemic events during skin inflammation. It has been shown that CD1a can capture endogenous cellular lipids that broadly block T cell responses, suggesting its role in regulating immune reactions. In conditions such as atopic dermatitis and psoriasis, CD1a expression and reactivity have been linked to disease pathology. Moreover, CD1a has been implicated in the pathogenesis of various diseases, including mycobacterial infections and certain types of cancer. It can serve as a biomarker for disease diagnosis, monitoring, and personalized treatment strategies.

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