L-selectin, also known as CD62L, is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Its function in leukocyte trafficking is highlighted by its role in lymphocyte homing to secondary lymphoid tissues. It mediates the tethering and rolling of lymphocytes on high endothelial venules (HEVs) in peripheral lymph nodes via interactions with glycoproteins expressing sLex epitopes. This process is essential for the proper functioning of the immune system, allowing for the recirculation of lymphocytes and their migration to sites of inflammation. In addition to its role in immune cell trafficking, L-selectin has been implicated in the adhesion of blastocysts to the endometrium during the implantation process in the female reproductive tract. It also plays a role in the recruitment of leukocytes during inflammation and in the homing of lymphocytes.