EGFR (L858R) Recombinant Rabbit mAb (SDT-421-202),specification,price,image-Bio-Equip in China

Product Detail
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Product Specification

Host	Rabbit
Antigen	EGFR (L858R)
Synonyms	Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; ERBB; ERBB1; HER1
Immunogen	Synthetic Peptide
Location	Cell membrane, Endoplasmic reticulum membrane
Accession	P00533
Clone Number	SDT-421-202
Antibody Type	Recombinant mAb
Isotype	IgG
Application	WB, IHC-P, IP
Reactivity	Hu
Positive Sample	H1975
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
Dot Blot	1:1000
WB	1:1000	Hu
IP	1:50	Hu
IHC-P	1:100-1:200	Hu

Background

EGFR is a 170 kDa transmembrane receptor that induces tyrosine kinase activity affecting cell growth. EGFR mutations can occur in various parts of the gene. In NSCLC, the mutations occur almost exclusively in the exons encoding the kinase domain (exons 18 to 21). They most commonly include the in-frame deletion of exon 19 (del19) and L858R mutation in exon 21.Del19 constitutes 44–51%, and exon 21 L858R mutation constitutes 38–40%.