Phospho-Syk (Tyr525/526) refers to the phosphorylation of the tyrosine kinase Syk at the tyrosine residues 525 and 526. This post-translational modification is crucial for the activation of Syk, which plays a significant role in various signaling pathways, particularly those involved in immune cell activation and function. Syk is a non-receptor tyrosine kinase that is involved in the regulation of immune responses, including B cell receptor signaling, Fc receptor signaling, and cytokine receptor signaling. Phosphorylation at Tyr525/526 is thought to be important for the full activation of Syk and its downstream signaling events, which can include the activation of other kinases such as phospholipase C gamma 2 (PLCγ2) and the mitogen-activated protein kinases (MAPKs).