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ROCK1 Recombinant Rabbit mAb (S-1304-153)
ROCK1 Recombinant Rabbit mAb (S-1304-153)
Origin of place Singapore
Model S0B1040-25μl
Supplier ANT BIO PTE.LTD.
Price 100
Hits 1
Updated 8/27/2025
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Product Specification


HostRabbit
AntigenROCK1
SynonymsRho-associated protein kinase 1; Renal carcinoma antigen NY-REN-35; Rho-associated, coiled-coil-containing protein kinase 1; ROCK-I; p160 ROCK-1 (p160ROCK)
ImmunogenSynthetic Peptide
LocationCytoplasm
AccessionQ13464
Clone NumberS-1304-153
Antibody TypeRecombinant mAb
IsotypeIgG
ApplicationWB, ICC, IP
ReactivityHu, Ms, Rt
Positive SampleHeLa, HepG2, Jurkat, NIH/3T3, C6
Predicted ReactivityRb
PurificationProtein A
Concentration0.5 mg/ml
ConjugationUnconjugated
Physical AppearanceLiquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


applicationdilutionspecies
WB1:1000Hu, Ms, Rt
IP1:50Hu
ICC1:500Hu, Ms

Background

ROCK1 (Rho-associated coiled-coil kinase 1) is a serine/threonine protein kinase that plays a crucial role in various cellular processes, including cell proliferation, migration, adhesion, and cytoskeletal remodeling. ROCK1 is involved in the regulation of the actin cytoskeleton and stress fiber formation. It achieves this by phosphorylating and modulating the activity of a range of actin-binding proteins and intermediate filament proteins. The kinase activity of ROCK1 is regulated by its interaction with the small GTPase RhoA. When RhoA is activated, it binds to the Rho-binding domain (RBD) of ROCK1, leading to a conformational change that relieves the auto-inhibition of the kinase domain and enhances ROCK1's catalytic activity. ROCK1 has been implicated in the pathogenesis of several diseases, including cancer, cardiovascular diseases, and neurological disorders. In cancer, ROCK1 has been shown to promote cell proliferation and survival, making it a potential therapeutic target for cancer treatment. In the context of cardiovascular diseases, ROCK1 activity has been associated with hypertension and pulmonary hypertension, as well as the regulation of vascular tone and remodeling.

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