p27 Kip1 Recombinant Rabbit mAb (SDT-361-310),specification,price,image-Bio-Equip in China

Product Detail
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Product Specification

Host	Rabbit
Antigen	p27 Kip1
Synonyms	Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor p27; Cdkn1b; KIP-1
Immunogen	Synthetic Peptide
Location	Nucleus, Cytoplasm
Accession	P46414
Clone Number	SDT-361-310
Antibody Type	Recombinant mAb
Isotype	IgG
Application	WB, IHC-P, IP
Reactivity	Hu, Ms, Rt
Positive Sample	Daudi, HeLa, MCF7, SH-SY5Y, Jurkat, Raji, NIH/3T3, C6
Predicted Reactivity	Fg, Ct
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
WB	1:1000	Hu, Ms, Rt
IP	1:50	Hu
IHC-P	1:500	Hu, Ms, Rt

Background

p27 KIP1 is a member of the Cyclin Inhibitory Protein/Kinase Inhibitory Protein (CIP/KIP) family of cyclin-dependent kinase (Cdk) inhibitors. It plays roles in all phases of the cell division cycle. Its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes enforces the G1 restriction point. Thus, important cellular functions as the cell division cycle, respiration, RNA processing, translation, and cell adhesion, are under p27 KIP1 regulation. Loss or reduced expression is associated with poor outcome in carcinoma of breast, prostate, GI tract and lung.