Low-density lipoprotein receptor-related protein 1 (LRP1) is a critical endocytic receptor involved in the transport and internalization of various ligands, including lipoproteins, proteases, and cytokines, playing a significant role in lipid metabolism, inflammation, and tissue repair. It is also implicated in the pathogenesis of Alzheimer's disease by regulating the uptake and spread of tau protein, and has been identified as a potential target for enhancing drug delivery across the blood-labyrinth barrier in the inner ear, offering a promising avenue for the treatment of hearing disorders.