Phospho-TAK1 (Ser439) is a significant biomarker for the activation of TAK1 (Transforming growth factor-β activated kinase 1), which is a mitogen-activated protein kinase kinase kinase (MAP3K) involved in various cellular signaling pathways, including the MAPK and NF-κB pathways. The phosphorylation of TAK1 at serine 439 (or 412 in rodents) is a key event in its activation process. This modification allows TAK1 to interact with other proteins and initiate downstream signaling cascades that regulate cell growth, survival, and inflammation. The detection of Phospho-TAK1 (Ser439) is typically performed using specific antibodies that recognize this phosphorylated form of the protein.