PI3 Kinase p110 β, also known as PIK3CB, is a catalytic subunit of the phosphoinositide 3-kinase (PI3K) family, which plays a critical role in cellular processes such as growth, metabolism, and survival. PI3Ks are enzymes that generate phosphoinositol lipids as second messengers, initiating multiple signal transduction cascades. The p110 β isoform has been shown to have distinct functions in different cellular contexts and contributes to cell growth and development, DNA replication, insulin sensitivity, tumorigenesis, and G-protein-coupled receptor-activated signaling.