UGGT1, known as UDP-Glucose Glycoprotein Glucosyltransferase 1, is an enzyme involved in the process of protein glycosylation. It is a soluble protein in the endoplasmic reticulum (ER) that selectively reglycosylates unfolded glycoproteins, providing quality control for protein trafficking out of the ER. In the process of hepatitis C virus (HCV) entry into cells, UGGT1 has been identified as a host factor that affects HCV entry by influencing SR-BI. As a biomarker, UGGT1 has potential applications in the diagnosis and treatment of cervical diseases such as cervical intraepithelial neoplasia and cervical squamous cell carcinoma.