H3K14ac is a post-translational modification form of histone H3, specifically referring to the acetylation of its 14th lysine residue. The modification of H3K14ac is closely related to gene transcription regulation. Acetylation modifications are generally associated with the activation of gene transcription, as they can alter the chromatin structure, making DNA more accessible to transcription factors and RNA polymerases. In certain studies, such as the research on novel products of Akkermansia muciniphila, the upregulation of H3K14ac promotes the transcription and secretion of heat shock protein 70 (HSP70) in cancer cells, thereby influencing the tumor microenvironment. Abnormal modifications of H3K14ac may be related to the occurrence and development of various diseases. For instance, in epithelial ovarian tumors, the expression of H3K14Ac may be associated with the histological grade and clinical stage of ovarian cancer. In studies on arsenic poisoning, H3K14ac is linked to arsenic poisoning and arsenic-induced early toxic effects, potentially providing an effective biomarker for early monitoring of arsenic poisoning.