Histone H3 (mono-methylated K36) refers to a specific form of histone H3 where the lysine residue at position 36 (K36) undergoes a monomethylation modification. This epigenetic modification, known as histone methylation, can influence the interaction between histones and DNA, thereby regulating gene transcription activity without altering the DNA sequence. The mono-methylation of H3K36 can be associated with either gene activation or repression, depending on the context and extent of methylation. In biological research, Histone H3 (mono-methylated K36) is often used as a tool or marker to study epigenetics, transcriptional regulation, cell differentiation, and other biological processes. Additionally, in disease research, abnormal patterns of histone methylation, including H3K36 methylation, may be associated with the development and progression of certain diseases.