Glycophorin C (GYPC), also known as Gerbich blood group antigen, is a minor sialic acid glycoprotein found in the human erythrocyte membrane. It plays a crucial role in maintaining erythrocyte stability and morphology, located on and integrated into the plasma membrane of red blood cells. The extracellular domain of GYPC may contain Gerbich antigens and receptors for Plasmodium falciparum merozoites. Beyond its role as a blood group determinant, GYPC strictly regulates the structural integrity of erythrocytes and immune interactions. In the medical field, variations or dysfunctions in GYPC may be associated with blood types, the Gerbich blood group, and malaria resistance. Therefore, research on Glycophorin C not only contributes to understanding erythrocyte physiology and blood group genetics but also provides new insights into the prevention and treatment of diseases like malaria.