Invivo anti-mouse PD-1 Recombinant mAb (D265A),specification,price,image-Bio-Equip in China

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Product Specification

Host	Mouse
Antigen	PD-1
Synonyms	Programmed cell death protein 1, mPD-1, CD279
Location	Cell membrane
Accession	Q02242
Clone Number	S-5001
Antibody Type	Recombinant mAb
Isotype	Mouse IgG1 D265A, κ
Isotype Control	Invivo mouse IgG1 isotype control (D265A)
Mutations	D265A
Application	In vivo blocking of PD-1/PD-L signaling
Reactivity	Ms
Purification	Protein G
Concentration	Lot specific* (generally 5 to 20 mg/ml)*
Endotoxin	<1EU/mg
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS pH7.4, containing no preservative
Stability & Storage	2 to 8 °C for 2 weeks under sterile conditions; -20 °C for 3 months under sterile conditions; -80 °C for 24 months under sterile conditions. Please avoid repeated freeze-thaw cycles.

Background

This antibody recognizes the same epitope as clone RMP1-14.

Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).