Anti-HER2 Monoclonal Antibody(Pertuzumab),specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Host	Human
Synonyms	Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein (MLN 19), Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340, ERBB2, MLN19, NEU, NGL
Accession	P04626
Clone Number	S-SC018
Antibody Type	Recombinant mAb
Isotype	IgG1,k
Application	Blocking of HER2 signaling Functional assays
Purification	Protein A
Concentration	2 mg/ml
Endotoxin	<1EU/mg
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS pH7.4, containing no preservative
Stability & Storage	12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution

application	dilution	species
ELISA	1.221-5000 ng/ml

Background

Pertuzumab is a monoclonal antibody used in combination with trastuzumab and docetaxel for the treatment of metastatic HER2-positive breast cancer; it also used in the same combination as a neoadjuvant in early HER2-positive breast cancer. It is the first-in-class of a kind of drug called a "HER dimerization inhibitor" — it inhibits the dimerization of HER2 with other HER receptors, which prevents them from signalling in ways that promote cell growth and proliferation.