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LC3B Recombinant Rabbit mAb (S-477-89)
LC3B Recombinant Rabbit mAb (S-477-89)
Origin of place Singapore
Model S0B0404-10μl
Supplier ANT BIO PTE.LTD.
Price 45
Hits 1
Updated 8/27/2025
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Product Specification


HostRabbit
AntigenLC3B
SynonymsMicrotubule-associated proteins 1A/1B light chain 3B, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, MAP1A/MAP1B light chain 3 B (MAP1A/MAP1B LC3 B), Microtubule-associated protein 1 light chain 3 beta, MAP1LC3B, MAP1ALC3
ImmunogenSynthetic Peptide
LocationCytoplasm, Cytoskeleton
AccessionQ9GZQ8
Clone NumberS-477-89
Antibody TypeRecombinant mAb
IsotypeIgG
ApplicationWB, IHC-P
ReactivityHu, Ms, Rt
PurificationProtein A
Concentration0.5 mg/ml
ConjugationUnconjugated
Physical AppearanceLiquid
Storage Buffer

PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300

Stability & Storage12 months from date of receipt / reconstitution, -20 °C as supplied.

Dilution


applicationdilutionspecies
WB1:1000
IHC1:1000

Background

LC3 is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3 is the most widely used marker of autophagosomes. Newly synthesized LC3's C-terminus is hydrolyzed by a cysteine protease called ATG4B exposing Gly120, termed LC3-I. LC3-I, through a series of ubiquitin-like reactions involving enzymes ATG7, ATG3, and ATG12-ATG5-ATG16, becomes conjugated to the head group of the lipid phosphatidylethanolamine. The lipid modified form of LC3, referred to as LC3-II, is believed to be involved in autophagosome membrane expansion and fusion events.

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