DR5 Recombinant Rabbit mAb (S-649-36),specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Host	Rabbit
Antigen	DR5
Synonyms	Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL receptor 2; TRAIL-R2), CD262, TNFRSF10B, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9
Immunogen	Synthetic Peptide
Location	Membrane
Accession	O14763
Clone Number	S-649-36
Antibody Type	Recombinant mAb
Application	WB, IP
Reactivity	Hu
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
WB	1:1000
IP	1:50

Background

DR5 is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.