PKC eta, also known as Protein Kinase C eta, is a member of the Protein Kinase C (PKC) family of enzymes. This serine/threonine-specific protein kinase plays crucial roles in various cellular processes, particularly in signal transduction, cell differentiation, and gene transcription regulation. PKC eta regulates keratinocyte differentiation by activating the MAPK13 (p38delta) activated protein kinase cascade. PKC eta mediates transcriptional activation of the transglutaminase 1 (TGM1) gene. Mutations in the gene have been linked to susceptibility to cerebral infarction.