CTIP2 (also known as BCL11B) is a transcription factor Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma. CTIP2 deficiency results in structural striatal defects, impaired spatial learning, and working memory deficits in mice. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Diseases associated with CTIP2 include Immunodeficiency and Intellectual Developmental Disorder with Speech Delay, Dysmorphic Facies, And T-Cell Abnormalities. Among its related pathways are NF-kappaB Signaling and Development and heterogeneity of the ILC family.