Adiponectin (also referred to as AdipoQ and Acrp30) is a 30 kDa protein hormone and adipokine that is secreted primarily by adipocytes. Plasma levels of adiponectin at around 2-30 μg/mL. Mature human Adiponectin consists of a 60 amino acid (aa) N-terminal collagenous region and a 137 aa C-terminal C1q/TNF-a-like globular domain. Adiponectin forms 90 kDa homotrimers that contain two disulfide-linked monomers and a third subunit which is noncovalently associated. Two trimers can be covalently linked to create a 180 kDa hexamer which associates into >300 kDa high molecular weight (HMW) Adiponectin. Adiponectin modulates several metabolic processes, including glucose regulation and fatty acid oxidation.