PI3 Kinase p85α Recombinant Rabbit mAb (S-328-24),specification,price,image-Bio-Equip in China

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Product Specification

Host	Rabbit
Antigen	PI3 Kinase p85α
Synonyms	Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase regulatory subunit alpha, PI3K regulatory subunit alpha, PtdIns-3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PtdIns-3-kinase regulatory subunit p85-alpha, PIK3R1
Immunogen	Synthetic Peptide
Location	Cytoplasm, Nucleus, Membrane
Accession	P27986
Clone Number	S-328-24
Antibody Type	Rabbit mAb
Application	WB, IHC-P, ICC, ICFCM, IP
Reactivity	Hu, Ms, Rt
Predicted Reactivity	Or, Bv
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
WB	1:1000
IP	1:50
IHC	1:250
ICFCM	1:500
ICC	1:500

Background

Cell proliferation and many other cell processes can be regulated through a signaling pathway that involves an enzyme called PI3K. This ‘heterodimeric’ enzyme is made up of two protein subunits, one of which is called p85α and inhibits the other subunit of the enzyme (known as p110) to prevent uncontrolled cell proliferation. Activation of the class 1A PI3K is gated, in part, by the p85α regulatory subunit, which contains a Src homology 3 (SH3) domain, two proline-rich (PR) regions (PR1 and PR2) separated by a Rho-GAP/BCR-homology (BH) domain, and two Src homology 2 (SH2) domains (nSH2, cSH2) flanking an inter-SH2 (iSH2) domain [PMID: 26222500].