Product Specification| Host | Rat | | Antigen | MLKL | | Synonyms | Mixed lineage kinase domain-like protein, hMLKL | | Immunogen | N/A | | Location | Cytoplasm, Nucleus, Membrane, Cell membrane | | Accession | Q8NB16 | | Clone Number | SDT-R195 | | Antibody Type | Rat mAb | | Isotype | IgG1 | | Application | WB, ICC | | Reactivity | Hu, Ms, Rt | | Purification | Protein G | | Concentration | 2 mg/ml | | Conjugation | Unconjugated | | Physical Appearance | Liquid | | Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 | | Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution| application | dilution | species | | WB | 1:1000 | null | | ICC | 1:50 | null |
BackgroundMixed lineage kinase domain-like (MLKL) is the executioner in the caspase-independent form of programmed cell death called necroptosis. Receptor-interacting serine/threonine protein kinase 3 (RIPK3) phosphorylates MLKL, triggering MLKL oligomerization, membrane translocation and membrane disruption [PMID: 34698396]. bio-equip.cn AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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