Catenin δ-1 (P120 Catenin) belongs to the β-serial protein family .p-120 catenin (along with α, β and γ catenins) connects the transmembrane protein E-cadherin to the actin cytoskeleton in the cell cytoplasm. It expresses in various normal epithelial tissues (including thyroid, breast, stomach, duodenal, liver, pancreas, colon, kidney, prostate, testicles), various non -epithelial tissues (including myocardial cells, neurons, gel cells To. p-120 regulates the transformation of calcium adhesion protein on the surface of the cells, thereby determining the E-calcium adhesive protein levels used in the cells, and then plays an important role in the adhesion of the cells. Many studies have shown that p-120 irregularly expression or lack of disobedience in a variety of cancer cells indicates that p-120 play a role in cancer-suppressing genes.