p40 Recombinant Rabbit mAb (SDT-166-36),specification,price,image-Bio-Equip in China

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Product Specification

Host	Rabbit
Antigen	p40
Synonyms	BC28
Immunogen	Synthetic Peptide
Location	Nucleus
Accession	Q9H3D4-4
Clone Number	SDT-166-36
Antibody Type	Recombinant mAb
Application	WB, IHC-P, IP
Reactivity	Hu
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
WB	1:1000	null
IP	1:50	null
IHC-P	1:500	null

Background

p63 (TAp63) is closely related to p40 (ΔNp63) as both proteins represent isoforms of the p63 gene with distinct molecular functions. While “full length” p63 (TAp63) activates p53 target genes such as p21 or BAX, the shorter transcript p40 (ΔNp63) inhibits activation of p53 and “full length” p63. Among carcinomas, p40 has approximately the same sensitivity as p63 but a higher specificity, as the TAp63 isoform is expressed more widespread in eg., adenocarcinomas. Moreover, p63 occur in lymphomas that are p40 negative.