S-RMab® SMAD4 Recombinant Rabbit mAb (SDT-R114),specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Host	Rabbit
Antigen	Smad4
Synonyms	Smad4, hSMAD4, DPC4
Immunogen	N/A
Location	Cytoplasm, Nucleus
Accession	Q13485
Clone Number	SDT-R114
Antibody Type	Rabbit mAb
Application	WB, IHC-P
Reactivity	Hu, Ms, Rt
Purification	Protein A
Concentration	0.25 mg/ml
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
WB	1:500	null
IHC-P	1:1000	null

Background

SMAD (mothers against decapentaplegic homologs) molecules are the core components in TGF-β signaling pathway. TGF-β binding to its receptor induces phosphorylation and activation of receptor-regulated SMADs (R-SMADs), SMAD2 and SMAD3, which subsequently associate with their partner SMAD4 and translocate from cytoplasm to nucleus. Formation of R-SMAD–SMAD4 complexes is essential in signaling of most TGF-β family members.