SMAD4 Recombinant Rabbit mAb (SDT-168-67),specification,price,image-Bio-Equip in China

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Product Specification

Host	Rabbit
Antigen	Smad4
Synonyms	Mothers against decapentaplegic homolog 4; MAD homolog 4; Mothers against DPP homolog 4; Deletion target in pancreatic carcinoma 4; hSMAD4
Immunogen	Synthetic Peptide
Location	Cytoplasm, Nucleus
Accession	Q13485
Clone Number	SDT-168-67
Antibody Type	Recombinant mAb
Isotype	IgG
Application	WB, IP
Reactivity	Hu, Ms, Rt
Predicted Reactivity	Bv, Pg
Purification	Protein A
Concentration	0.5 mg/ml
Conjugation	Unconjugated
Physical Appearance	Liquid
Storage Buffer	PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution

application	dilution	species
WB	1:1000	Hu, Ms, Rt
IP	1:50	Hu, Ms, Rt

Background

SMAD (mothers against decapentaplegic homologs) molecules are the core components in TGF-β signaling pathway. TGF-β binding to its receptor induces phosphorylation and activation of receptor-regulated SMADs (R-SMADs), SMAD2 and SMAD3, which subsequently associate with their partner SMAD4 and translocate from cytoplasm to nucleus. Formation of R-SMAD–SMAD4 complexes is essential in signaling of most TGF-β family members.