CD36 is a transmembrane glycoprotein that serves as a key fatty acid transporter and sensor, playing a crucial role in lipid metabolism. It is involved in the recognition and phagocytosis of lipids by macrophages and has been implicated in inflammatory responses and cardiovascular diseases. CD36 is also expressed in various immune cells and has been shown to regulate autophagy. Additionally, it is highly expressed in several types of cancer, where it promotes tumor progression by facilitating fatty acid uptake, epithelial-mesenchymal transition (EMT), and resistance to anticancer drugs. CD36 has emerged as a potential therapeutic target for metabolic diseases, cardiovascular conditions, and cancer.