CD8伪 is a crucial immune glycoprotein that serves as a co-receptor for MHC class I peptide complexes, facilitating the connection between T cells and antigens presented by antigen-presenting cells (APCs). It interacts with the T-cell receptor (TCR) and MHC class I molecules, recruits LCK kinase, and initiates multiple signaling pathways. CD8伪 can exist as either an 伪/尾 heterodimer or an 伪/伪 homodimer, with the 伪伪 homodimer being particularly abundant in intraepithelial lymphocytes (IELs) that protect mucosal surfaces. It is expressed on cytotoxic T cells (CTLs) and natural killer (NK) cells, playing a key role in cell-mediated immunity and the regulation of immune responses. Additionally, CD8伪 is involved in T cell activation and differentiation, and it is a biomarker for various diseases, including COVID-19 and certain cancers.