CD209, also known as DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Non-integrin), is a C-type lectin receptor primarily expressed on the surface of dendritic cells, macrophages, and certain endothelial cells. It plays a crucial role in the innate immune system by recognizing and binding to a wide range of pathogens, including viruses, bacteria, and fungi. CD209 is involved in mediating antigen endocytosis and degradation, facilitating the interaction between dendritic cells and T cells, and influencing immune responses. Additionally, it has been implicated in the binding of HIV-1 gp120, contributing to viral entry and infection. Research also suggests that CD209 may regulate macrophage polarization and neutrophil development, highlighting its importance in both innate and adaptive immunity.