The CD183 protein, also known as CXCR3, is a G protein-coupled seven-transmembrane receptor that primarily binds to CXC subfamily chemokines CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC). These chemokines are produced by local cells at sites of inflammation and are involved in the recruitment of inflammatory cells. CD183 is highly expressed on effector/memory T cells cultured in vitro and on T cells in various inflamed tissues. Additionally, it is expressed on NK cells, some T lymphocytes, and subsets of Treg cells, with a preference for expression on Th1-polarized cells. Activation of CD183 involves cellular responses such as integrin activation, cytoskeletal changes, and chemotactic migration. Due to its key role in inflammatory responses, CD183 has become a target for the development of small molecule antagonists, which may be used to treat a variety of inflammatory diseases.