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TIA1 Recombinant Rabbit mAb (S-R026)
TIA1 Recombinant Rabbit mAb (S-R026)
Origin of place Singapore
Model S0B2076-25μl
Supplier ANT BIO PTE.LTD.
Price 100
Hits 3
Updated 8/25/2025
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Product Specification


HostRabbit
AntigenTIA1
Synonymsp40-TIA-1
ImmunogenN/A
LocationCytoplasm, Nucleus
AccessionP31483
Clone NumberSDT-R026
Antibody TypeRabbit mAb
ApplicationWB, ICC, FC, IP
ReactivityHu
PurificationProtein A
Concentration0.5 mg/ml
Physical AppearanceLiquid
Storage BufferPBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


applicationdilutionspecies
ICC1:500null
WB1:1000null
IP1:25null
FC1:500null

Background

TIA1 or Tia1 cytotoxic granule-associated RNA binding protein is a 3'UTR mRNA binding protein that can bind the 5'TOP sequence of 5'TOP mRNAs. It is associated with programmed cell death (apoptosis) and regulates alternative splicing of the gene encoding the Fas receptor, an apoptosis-promoting protein. Under stress conditions, TIA1 localizes to cellular RNA-protein conglomerations called stress granules. It is encoded by the TIA1 gene.Mutations in the TIA1 gene have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, and Welander distal myopathy. It also plays a crucial role in the development of toxic oligomeric tau in Alzheimer's disease.

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