Monkeypox is a rare disease similar to smallpox caused by the monkeypox virus. It’s found mostly in areas of Africa, but has been seen in other regions of the world. It causes flu-like symptoms such as fever and chills, and a rash that can take weeks to clear. There’s no proven treatment for monkeypox, but it usually goes away on its own.Monkeypox Virus E8L binds to chondroitin sulfate on the cell surface to provide virion attachment to target cell. Antibody targeting D8, H3 and A27 (VACV) are able to block the viral adhesion to the host cell and thereforprotect from infection. Anti-MPXV E8L mAb is a human monoclonal antibody and is produced by mammalian expression system.