NTHL1 encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity. NTHL1 (Nth Like DNA Glycosylase 1) is a Protein Coding gene. Diseases associated with NTHL1 include Familial Adenomatous Polyposis 3 and Periampullary Adenoma. Among its related pathways are DNA damage_Role of Brca1 and Brca2 in DNA repair and Telomere C-strand (Lagging Strand) Synthesis.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000 ELISA 1:5000-20000.

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