PTPRQ belongs to the type III receptor-like protein-tyrosine phosphatase (PTPase) family. PTPRQ has low activity against phosphotyrosine, but is active against phosphatidylinositol phosphates that are involved in regulation of survival, proliferation, and subcellular architecture. The genomic region containing nt 391..910 of this sequence are inverted in the human reference genome (build 37). This portion of the RefSeq is inferred based on alignments of rat and mouse transcripts, and is supported by the human Celera assembly.In developing kidney, it localizes to the basal membrane of podocytes, beginning when podocyte progenitors can first be identified in the embryonic kidney (at protein level). Expressed in lung and kidney.

Human Phosphotidylinositol phosphatase PTPRQ (PTPRQ) ELISA Kit employs a two-site sandwich ELISA to quantitate PTPRQ in samples. An antibody specific for PTPRQ has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPTPRQ present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PTPRQ is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PTPRQ bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Phosphotidylinositol phosphatase PTPRQ (PTPRQ) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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