Adenylate cyclase type 6 is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.By Southern blot analysis of somatic cell hybrid DNAs, Gaudin et al. (1994) mapped the ADCY6 gene to chromosome 12. The homologous mouse gene is located on chromosome 15 in the F region.

Human Adenylate cyclase type 6 (ADCY6) ELISA Kit employs a two-site sandwich ELISA to quantitate ADCY6 in samples. An antibody specific for ADCY6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyADCY6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for ADCY6 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of ADCY6 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Adenylate cyclase type 6 (ADCY6) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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