AIM2 plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. AIM2 was expressed as a 39-kD protein following in vitro transcription/translation in rabbit reticulocyte lysate or transfection in a murine epithelial cell line. Cell fractionation showed that AIM2 localized primarily to the cytoplasm of transfected mouse cells.Chromosome alterations in malignant melanoma most frequently include translocations and deletions on chromosome 1 or 6 . AIM2 encodes a deduced 344-amino acid protein that contains a conserved sequence domain of approximately 200 amino acids shared with interferon-inducible genes as well as a tyrosine kinase phosphorylation site.

Human Interferon-inducible protein AIM2 (AIM2) ELISA Kit employs a two-site sandwich ELISA to quantitate AIM2 in samples. An antibody specific for AIM2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyAIM2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for AIM2 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of AIM2 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Interferon-inducible protein AIM2 (AIM2) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.