TMPRSS4 encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene.A weak TMPRSS4 signal was detected in normal tissues of the gastrointestinal tract and in some of the urogenital tract but was not expressed in any other normal tissues. The authors suggested that TMPRSS4 may be important in processes involved in metastasis formation and tumor invasion.

Human Transmembrane protease serine 3 (TMPRSS3) ELISA Kit employs a two-site sandwich ELISA to quantitate TMPRSS3 in samples. An antibody specific for TMPRSS3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyTMPRSS3 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for TMPRSS3 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of TMPRSS3 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Transmembrane protease serine 3 (TMPRSS3) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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