The galectins constitute a large family of carbohydrate-binding proteins that function in many systems both intracellularly and following secretion.Galectins contain either one or two carbohydrate recognition domains (CRR) which mediate recognition of N-acetyl-lactosamine-containing glycoproteins. Galectin-2, a lectin binding to ß-galactoside, was found to trigger apoptosis of activated T cells and leaves naive or memory T cells unaltered. Cytokine secretion of activated T cells was significantly shifted to the Th2 profile. In vivo experiments showed a significant decrease of bowel inflammation during the course of several days in galectin-2 treated mice featuring DSS-colitis. Furthermore, contact hypersensitivity (CHS) responses were reduced significantly in Galectin-2 treated mice after sensitization to contact allergens.

Rat Galectin-2 (LGALS2) ELISA Kit employs a two-site sandwich ELISA to quantitate LGALS2 in samples. An antibody specific for LGALS2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyLGALS2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for LGALS2 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of LGALS2 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Rat Galectin-2 (LGALS2) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.