Indolethylamine N-methyltransferase (INMT) catalyzes the N-methylation of tryptamine and structurally related compounds.The predicted 263-amino acid human INMT protein contains the signature sequences of methyltransferases, referred to as RI, RII, and RIII. Human INMT shares 88% amino acid sequence identity with rabbit INMT, 58% identity with mouse thioether methyltransferase, 53% identity with both human and mouse nicotinamide methyltransferase (NNMT), and 38% identity with human phenylethanolamine N-methyltransferase (PNMT). The INMT gene is 5,471 bp in length and contains 3 exons. Northern blot analysis detected an approximately 2.7-kb INMT transcript in most of the 35 human tissues tested, with highest expression in adult thyroid, adult adrenal gland, adult lung, and fetal lung.

Rabbit Indolethylamine N-methyltransferase (INMT) ELISA Kit employs a two-site sandwich ELISA to quantitate INMT in samples. An antibody specific for INMT has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyINMT present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for INMT is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of INMT bound in the initial step. The color development is stopped and the intensity of the color is measured.

Rabbit Indolethylamine N-methyltransferase (INMT) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.