Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins. Involved in placental, cardiac, hepatic and embryonic development.

Mouse Nuclear receptor coactivator 6 (NCOA6) ELISA Kit employs a two-site sandwich ELISA to quantitate NCOA6 in samples. An antibody specific for NCOA6 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyNCOA6 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for NCOA6 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of NCOA6 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Mouse Nuclear receptor coactivator 6 (NCOA6) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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