PGD2 is a prostaglandin which binds to the receptor PTGDR, as well as CRTH2. It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, basophils. In mammalian organs, large amounts of PGD2 are found in the brain, in mast cells and found nowhere else. It is critical to development of allergic diseases such as asthma.Causes a contraction of the bronchial airways. The concentration of PGD2 in asthma-patients is 10 times higher than in control patients, especially after it is brought into contact with allergens. Involved in the regulation of reducing body temperature, in sleep, and acts opposite to prostaglandin E2.

Mouse Prostaglandin D2 (PGD2) ELISA Kit employs a two-site sandwich ELISA to quantitate PGD2 in samples. An antibody specific for PGD2 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPGD2 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PGD2 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PGD2 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Mouse Prostaglandin D2 (PGD2) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.