Tandem mass spectrometry of receptor peptides yielded partial amino acid sequences that allowed the identification of cDNA clones corresponding to the A39R receptor, called VESPR, The VESPR protein contains 1,568 amino acids and has a molecular mass of approximately 200 kD. Sequence analysis indicated that VESPR is a transmembrane glycoprotein and a member of the plexin family. Additional sequence analysis identified a semaphorin-like domain within this family, suggesting an evolutionary relationship between receptor and ligand. VESPR transcript in brain, lung, spleen, and placenta, and an approximately 7.5-kb VESPR transcript in heart. A39R upregulated ICAM1 on, and induced cytokine production from, human monocytes, suggesting that this viral protein can function as an immune modulator during virus infection.

Mouse Plexin-C1 (PLXNC1) ELISA Kit employs a two-site sandwich ELISA to quantitate PLXNC1 in samples. An antibody specific for PLXNC1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyPLXNC1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for PLXNC1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of PLXNC1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Mouse Plexin-C1 (PLXNC1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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Abbkine Scientific Co., Ltd. was founded by a number of scientists and marketing experts in the field of life science in California in 2012. With growing demands from Asia Pacific, it move its headquarters to China. Combining cutting edge technology from United States with China's manufacturing engineering and cost advantages, we aim to provide innovative, high quality assay kits, recombinant proteins, antibodies and other research tools to accelerate life science fundamental research, drug discovery, etc.