PCGF6 contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.Mouse and human MBLR share 87% sequence identity, and the central domain of MBLR shares 38% identity with the corresponding regions of MEL18 and BMI1. A minor transcript of 4.5 kb was also expressed in some tissues. RT-PCR confirmed ubiquitous expression.

Human Mannma binding lectin receptor (MBLR) ELISA Kit employs a two-site sandwich ELISA to quantitate MBLR in samples. An antibody specific for MBLR has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyMBLR present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for MBLR is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of MBLR bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Mannma binding lectin receptor (MBLR) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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