Streuli et al. (1980) showed that at least 3 different IFN-alpha genes are expressed in man. Furthermore, study of genomic DNA revealed the presence of at least 8 IFN genes.Nagata et al. (1980) found that the alpha-interferon genes are devoid of intervening sequences. Using radioactive probes from purified cDNA clones of interferons, Owerbach et al. (1981) located at least 8 leukocyte interferon genes and a fibroblast interferon gene on chromosome 9. Shows et al. (1982) found that the alpha- and beta-interferon genes are on 9p. The mapping to 9pter-q12 was accomplished by blot hybridization of cloned interferon cDNA to DNA from human-mouse cell hybrids with a translocation involving chromosome 9.

Human Interferon alpha/beta receptor 1 (IFNa/bR1) ELISA Kit employs a two-site sandwich ELISA to quantitate IFNa/bR1 in samples. An antibody specific for IFNa/bR1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anyIFNa/bR1 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for IFNa/bR1 is added to the wells. After washing, Streptavidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of IFNa/bR1 bound in the initial step. The color development is stopped and the intensity of the color is measured.

Human Interferon alpha/beta receptor 1 (IFNa/bR1) ELISA Kit listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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